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You need a business license from the city. Please see Business License or Permit cost for more information on what type of business require a license and costs.
According to the San Bruno Municipal Code 3.08.020, it is unlawful for any person to commence, transact or carry on any business without first having procured a license from the City to do so. Those with home occupation businesses, apartment owners (with three or more living units), persons with commercial property rentals, outside contractors working in town on a project are all required to obtain City licenses. Contact the San Bruno Portal at 650-273-4371 for more information.
Contact the Planning Division 650-616-7074 first to make sure that the business would meet zoning requirements.